Delivery route, MyD88 signaling and cross-priming events determine the anti-tumor efficacy of an Adenovirus based melanoma vaccine

Adenovirus (Ad)-based vaccines are considered for cancer immunotherapy, yet, detailed knowledge on their mechanism of action and optimal delivery route for anti-tumor efficacy is lacking. Here, we compared the anti-tumor efficacy of an Ad-based melanoma vaccine after intradermal, intravenous, intran...

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Main Authors: Hangalapura, Basav N, Oosterhoff, Dinja, Gupta, Tarun, de Groot, Jan, Wijnands, Pepijn GJTB, van Beusechem, Victor W., den Haan, Joke, Tüting, Thomas, van den Eertwegh, Alfons JM, Curiel, David T, Scheper, Rik J, de Gruijl, Tanja D
Format: Artigo
Jezik:Inglês
Izdano: 2011
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3058128/
https://ncbi.nlm.nih.gov/pubmed/21272606
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.vaccine.2011.01.022
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