Endosomal accumulation of APP in wobbler motor neurons reflects impaired vesicle trafficking: Implications for human motor neuron disease

BACKGROUND: The cause of sporadic amyotrophic lateral sclerosis (ALS) is largely unknown but hypotheses about disease mechanisms include oxidative stress, defective axonal transport, mitochondrial dysfunction and disrupted RNA processing. Whereas familial ALS is well represented by transgenic mutant...

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Autors principals: Palmisano, Ralf, Golfi, Panagiota, Heimann, Peter, Shaw, Christopher, Troakes, Claire, Schmitt-John, Thomas, Bartsch, Jörg W
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2011
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3058068/
https://ncbi.nlm.nih.gov/pubmed/21385376
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2202-12-24
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