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Carbamazepine co-administration with an oral contraceptive: effects on steroid pharmacokinetics, ovulation, and bleeding

PURPOSE: Anti-epileptic drugs (AEDs) are widely used in reproductive-age women. The AED carbamazepine (CBZ) induces the hepatic cytochrome p450 system accelerating hormone metabolism. We sought to assess the pharmacodynamic effects of CBZ on breakthrough bleeding and ovulation during OC use. METHODS...

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Detalhes bibliográficos
Main Authors: Davis, Anne R., Westhoff, Carolyn L., Stanczyk, Frank Z.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3057928/
https://ncbi.nlm.nih.gov/pubmed/21204827
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1528-1167.2010.02917.x
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