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Complex Contribution of Cyclophilin D to Ca(2+)-induced Permeability Transition in Brain Mitochondria, with Relation to the Bioenergetic State
Cyclophilin d (cypD)-deficient mice exhibit resistance to focal cerebral ischemia and to necrotic but not apoptotic stimuli. To address this disparity, we investigated isolated brain and in situ neuronal and astrocytic mitochondria from cypD-deficient and wild-type mice. Isolated mitochondria were c...
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| Auteurs principaux: | , , , , , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
American Society for Biochemistry and Molecular Biology
2011
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3057831/ https://ncbi.nlm.nih.gov/pubmed/21173147 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.196600 |
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