Artesunate Activates Mitochondrial Apoptosis in Breast Cancer Cells via Iron-catalyzed Lysosomal Reactive Oxygen Species Production

The antimalarial agent artesunate (ART) activates programmed cell death (PCD) in cancer cells in a manner dependent on the presence of iron and the generation of reactive oxygen species. In malaria parasites, ART cytotoxicity originates from interactions with heme-derived iron within the food vacuol...

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Detalhes bibliográficos
Main Authors: Hamacher-Brady, Anne, Stein, Henning A., Turschner, Simon, Toegel, Ina, Mora, Rodrigo, Jennewein, Nina, Efferth, Thomas, Eils, Roland, Brady, Nathan R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3057810/
https://ncbi.nlm.nih.gov/pubmed/21149439
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.210047
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