Exploiting Cross-reactivity to Neutralize Two Different Scorpion Venoms with One Single Chain Antibody Fragment

We report the optimization of a family of human single chain antibody fragments (scFv) for neutralizing two scorpion venoms. The parental scFv 3F recognizes the main toxins of Centruroides noxius Hoffmann (Cn2) and Centruroides suffusus suffusus (Css2), albeit with low affinity. This scFv was subjec...

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Detalhes bibliográficos
Main Authors: Riaño-Umbarila, Lidia, Contreras-Ferrat, Gabriel, Olamendi-Portugal, Timoteo, Morelos-Juárez, Citlalli, Corzo, Gerardo, Possani, Lourival D., Becerril, Baltazar
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3057807/
https://ncbi.nlm.nih.gov/pubmed/21156801
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.189175
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