Ubiquitination Regulates the Internalization, Endolysosomal Sorting, and Signaling of the Erythropoietin Receptor

Ubiquitination is a common mechanism of down-regulation of mitogenic receptors. Here, we show that ubiquitination of the erythropoietin receptor (EpoR) at Lys(256) is necessary and sufficient for efficient Epo-induced receptor internalization, whereas ubiquitination at Lys(428) promotes trafficking...

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Sparad:
Bibliografiska uppgifter
Huvudupphovsmän: Bulut, Gamze Betul, Sulahian, Rita, Ma, Yue, Chi, Nai-wen, Huang, Lily Jun-shen
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Biochemistry and Molecular Biology 2011
Ämnen:
Signal Transduction
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3057794/
https://ncbi.nlm.nih.gov/pubmed/21183685
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.186890
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