Cbl ubiquitination of p85 is essential for Epo-induced EpoR endocytosis

Erythropoietin (Epo) binding to the Epo receptor (EpoR) elicits downstream signaling that is essential for red blood cell production. One important negative regulatory mechanism to terminate Epo signaling is Epo-induced EpoR endocytosis and degradation. Defects in this mechanism play a key role in t...

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Bibliografiset tiedot
Päätekijät: Bulut, Gamze B., Sulahian, Rita, Yao, Huiyu, Huang, Lily Jun-shen
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society of Hematology 2013
Aiheet:
Red Cells, Iron, and Erythropoiesis
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3854114/
https://ncbi.nlm.nih.gov/pubmed/24113870
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2013-05-506212
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