Cbl ubiquitination of p85 is essential for Epo-induced EpoR endocytosis

Erythropoietin (Epo) binding to the Epo receptor (EpoR) elicits downstream signaling that is essential for red blood cell production. One important negative regulatory mechanism to terminate Epo signaling is Epo-induced EpoR endocytosis and degradation. Defects in this mechanism play a key role in t...

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Detalhes bibliográficos
Main Authors: Bulut, Gamze B., Sulahian, Rita, Yao, Huiyu, Huang, Lily Jun-shen
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2013
Assuntos:
Red Cells, Iron, and Erythropoiesis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3854114/
https://ncbi.nlm.nih.gov/pubmed/24113870
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2013-05-506212
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