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Cbl ubiquitination of p85 is essential for Epo-induced EpoR endocytosis
Erythropoietin (Epo) binding to the Epo receptor (EpoR) elicits downstream signaling that is essential for red blood cell production. One important negative regulatory mechanism to terminate Epo signaling is Epo-induced EpoR endocytosis and degradation. Defects in this mechanism play a key role in t...
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| Autors principals: | , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Society of Hematology
2013
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3854114/ https://ncbi.nlm.nih.gov/pubmed/24113870 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2013-05-506212 |
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