Drug efflux by Breast Cancer Resistance Protein (BCRP) is a mechanism of resistance to the benzimidazole insulin-like growth factor receptor/insulin receptor inhibitor, BMS-536924

BACKGROUND: Preclinical investigations have identified insulin-like growth factor (IGF) signaling as a key mechanism for cancer growth and resistance to clinically useful therapies in multiple tumor types, including breast cancer. Thus, agents targeting and blocking IGF signaling have promise in the...

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Hauptverfasser: Hou, Xiaonan, Huang, Fei, Carboni, Joan M., Flatten, Karen, Asmann, Yan W., Eyck, Cynthia Ten, Nakanishi, Takeo, Tibodeau, Jennifer D., Ross, Douglas D., Gottardis, Marco M., Erlichman, Charles, Kaufmann, Scott H., Haluska, Paul
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2011
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3057506/
https://ncbi.nlm.nih.gov/pubmed/21220496
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-10-0438
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