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A role for the Ca(2+) channel TRPML1 in gastric acid secretion, based on analysis of knockout mice
BACKGROUND & AIMS: Mutations in TRPML1, a lysosomal Ca(2+)-permeable TRP channel, lead to mucolipidosis type IV (MLIV), a neurodegenerative lysosomal storage disease. An unusual feature of MLIV is constitutive achlorhydria. We produced Trpml1(−/−) (null) mice to investigate the requirement for t...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3057336/ https://ncbi.nlm.nih.gov/pubmed/21111738 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2010.11.040 |
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