Comparing methods to estimate treatment effects on a continuous outcome in multicentre randomized controlled trials: A simulation study

BACKGROUND: Multicentre randomized controlled trials (RCTs) routinely use randomization and analysis stratified by centre to control for differences between centres and to improve precision. No consensus has been reached on how to best analyze correlated continuous outcomes in such settings. Our obj...

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Bibliographic Details
Main Authors: Chu, Rong, Thabane, Lehana, Ma, Jinhui, Holbrook, Anne, Pullenayegum, Eleanor, Devereaux, Philip James
Format: Artigo
Language:Inglês
Published: BioMed Central 2011
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3056845/
https://ncbi.nlm.nih.gov/pubmed/21338524
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2288-11-21
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