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Insulin-like growth factor-I gene delivery to astrocytes reduces their inflammatory response to lipopolysaccharide

BACKGROUND: Insulin-like growth factor-I (IGF-I) exerts neuroprotective actions in the central nervous system that are mediated at least in part by control of activation of astrocytes. In this study we have assessed the efficacy of exogenous IGF-I and IGF-I gene therapy in reducing the inflammatory...

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Bibliografiske detaljer
Main Authors: Bellini, Maria J, Hereñú, Claudia B, Goya, Rodolfo G, Garcia-Segura, Luis M
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2011
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3056784/
https://ncbi.nlm.nih.gov/pubmed/21371294
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-2094-8-21
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