The novel receptor tyrosine kinase Axl is constitutively active in B-cell chronic lymphocytic leukemia and acts as a docking site of nonreceptor kinases: implications for therapy

Recently, we detected that chronic lymphocytic leukemia (CLL) B-cell–derived microvesicles in CLL plasma carry a constitutively phosphorylated novel receptor tyrosine kinase (RTK), Axl, indicating that Axl was acquired from the leukemic B cells. To examine Axl status in CLL, we determined the expres...

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Bibliografiska uppgifter
Huvudupphovsmän: Ghosh, Asish K., Secreto, Charla, Boysen, Justin, Sassoon, Traci, Shanafelt, Tait D., Mukhopadhyay, Debabrata, Kay, Neil E.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society of Hematology 2011
Ämnen:
Lymphoid Neoplasia
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3056640/
https://ncbi.nlm.nih.gov/pubmed/21135257
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-09-305649
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