Basal Bone Phenotype and Increased Anabolic Responses to Intermittent Parathyroid Hormone in Healthy Male COX-2 Knockout Mice

Cyclooxygenase-2 (COX-2) knockout (KO) mice in inbred strains can have renal dysfunction with secondary hyperparathyroidism (HPTH), making direct effects of COX-2 KO on bone difficult to assess. COX-2 KO mice in an outbred CD-1 background did not have renal dysfunction but still had two-fold elevate...

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Main Authors: Xu, Manshan, Choudhary, Shilpa, Voznesensky, Olga, Gao, Qi, Adams, Douglas, Diaz-Doran, Vilmaris, Wu, Qian, Goltzman, David, Raisz, Lawrence G., Pilbeam, Carol C.
Format: Artigo
Sprog:Inglês
Udgivet: 2010
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3056501/
https://ncbi.nlm.nih.gov/pubmed/20471507
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bone.2010.05.006
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