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Nonstop mRNA Decay Initiates at the Ribosome
The translation machinery deciphers genetic information encoded within mRNAs to synthesize proteins needed for various cellular functions. Defective mRNAs that lack in-frame stop codons trigger nonproductive stalling of ribosomes. We investigated how cells deal with such defective mRNAs, and present...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2010
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3056498/ https://ncbi.nlm.nih.gov/pubmed/21091502 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2958.2010.07396.x |
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