Prophylaxis of Graft-Versus-Host Disease in Unrelated Donor Transplantation With Pentostatin, Tacrolimus, and Mini-Methotrexate: A Phase I/II Controlled, Adaptively Randomized Study

PURPOSE: Acute graft-versus-host disease (aGVHD) is a major cause of morbidity and mortality after matched unrelated, related, or mismatched related donor hematopoietic stem-cell transplantation (HSCT). Improved GVHD prevention methods are needed. Pentostatin, an adenosine deaminase inhibitor, leads...

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Hlavní autoři: Parmar, Simrit, Andersson, Borje S., Couriel, Daniel, Munsell, Mark F., Fernandez-Vina, Marcelo, Jones, Roy B., Shpall, Elizabeth J., Popat, Uday, Anderlini, Paolo, Giralt, Sergio, Alousi, Amin, Cano, Pedro, Bosque, Doyle, Hosing, Chitra, de Padua Silva, Leandro, Westmoreland, Michael, Wathen, J. Kyle, Berry, Donald, Champlin, Richard E., de Lima, Marcos J.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Clinical Oncology 2011
Témata:
Original Reports
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3056464/
https://ncbi.nlm.nih.gov/pubmed/21149654
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/JCO.2010.30.6357
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