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Camel heavy-chain antibodies: diverse germline V(H)H and specific mechanisms enlarge the antigen-binding repertoire

The antigen-binding site of the camel heavy-chain antibodies devoid of light chain consists of a single variable domain (V(H)H) that obviously lacks the V(H)–V(L) combinatorial diversity. To evaluate the extent of the V(H)H antigen-binding repertoire, a germline database was constructed from PCR-amp...

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Sonraí Bibleagrafaíochta
Main Authors: Nguyen, Viet Khong, Hamers, Raymond, Wyns, Lode, Muyldermans, Serge
Formáid: Artigo
Teanga:Inglês
Foilsithe: Oxford University Press 2000
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC305632/
https://ncbi.nlm.nih.gov/pubmed/10698934
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/19.5.921
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