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Molecular basis for the preferential cleft recognition by dromedary heavy-chain antibodies
Clefts on protein surfaces are avoided by antigen-combining sites of conventional antibodies, in contrast to heavy-chain antibodies (HCAbs) of camelids that seem to be attracted by enzymes’ substrate pockets. The explanation for this pronounced preference of HCAbs was investigated. Eight single doma...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2006
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1450215/ https://ncbi.nlm.nih.gov/pubmed/16537393 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0505379103 |
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