Effects of Genetic Polymorphisms of Thymidylate Synthase (TS) and Methylenetetrahydrofolate Reductase (MTHFR) Along With Folate Intake on Clinical Outcome of Gastric Cancer Patients Treated With Fluorouracil-Based Chemotherapy

BACKGROUND: Several reports have evaluated treatment outcome of fluorouracil (FU)-treated gastric cancer patients based on genetic polymorphisms of TS (thymidylate synthase), a key target of FU, or MTHFR (methylenetetrahydrofolate reductase), a key enzyme of folate metabolism. However, the clinical...

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Autors principals: Shitara, Kohei, Matsuo, Keitaro, Yokota, Tomoya, Takahari, Daisuke, Ura, Takashi, Sawaki, Akira, Kawai, Hiroki, Ito, Seiji, Tajima, Kazuo, Muro, Kei, Tanaka, Hideo
Format: Artigo
Idioma:Inglês
Publicat: International Society of Gastrointestinal Oncology 2010
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3056299/
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