A Live-Attenuated HSV-2 ICP0 (−) Virus Elicits 10 to 100 Times Greater Protection against Genital Herpes than a Glycoprotein D Subunit Vaccine

Glycoprotein D (gD-2) is the entry receptor of herpes simplex virus 2 (HSV-2), and is the immunogen in the pharmaceutical industry's lead HSV-2 vaccine candidate. Efforts to prevent genital herpes using gD-2 subunit vaccines have been ongoing for 20 years at a cost in excess of $100 million. To...

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Главные авторы: Halford, William P., Püschel, Ringo, Gershburg, Edward, Wilber, Andrew, Gershburg, Svetlana, Rakowski, Brandon
Формат: Artigo
Язык:Inglês
Опубликовано: Public Library of Science 2011
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Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3055896/
https://ncbi.nlm.nih.gov/pubmed/21412438
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0017748
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