BMP-12 Treatment of Adult Mesenchymal Stem Cells In Vitro Augments Tendon-Like Tissue Formation and Defect Repair In Vivo

We characterized the differentiation of rat bone marrow-derived mesenchymal stem cells (BM-MSCs) into tenocyte-like cells in response to bone morphogenetic protein-12 (BMP-12). BM-MSCs were prepared from Sprague-Dawley rats and cultured as monolayers. Recombinant BMP-12 treatment (10 ng/ml) of BM-MS...

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Bibliographic Details
Main Authors: Lee, Jonathan Y., Zhou, Zuping, Taub, Peter J., Ramcharan, Melissa, Li, Yonghui, Akinbiyi, Takintope, Maharam, Edward R., Leong, Daniel J., Laudier, Damien M., Ruike, Takuya, Torina, Phillip J., Zaidi, Mone, Majeska, Robert J., Schaffler, Mitchell B., Flatow, Evan L., Sun, Hui B.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2011
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3055887/
https://ncbi.nlm.nih.gov/pubmed/21412429
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0017531
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