Thrombospondin-1 Regulates the Normal Prostate In Vivo Through Angiogenesis and TGF-β Activation

Castration experiments in rodents demonstrate that the stromal vasculature is critical to the androgen-mediated prostate growth regulation. However, the role of angiogenesis inhibitors, such as thrombospondin-1 (TSP-1), in this process is unclear. TSP-1 is a multi-functional glycoprotein that can fu...

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Detalhes bibliográficos
Main Authors: Fitchev, Philip P., Wcislak, Susan M., Lee, Chung, Bergh, Anders, Brendler, Charles B., Stellmach, Veronica M., Crawford, Susan E., Mavroudis, Constantine D., Cornwell, Mona L., Doll, Jennifer A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3055786/
https://ncbi.nlm.nih.gov/pubmed/20458281
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/labinvest.2010.90
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