In Glaucoma the Upregulated Truncated TrkC.T1 Receptor Isoform in Glia Causes Increased TNF-α Production, Leading to Retinal Ganglion Cell Death

PURPOSE. Glaucoma is a distinct neuropathy characterized by the chronic and progressive death of retinal ganglion cells (RGCs). The etiology of RGC death remains unknown. Risk factors for glaucomatous RGC death are elevated intraocular pressure and glial production of tumor necrosis factor-alpha (TN...

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Autori principali: Bai, Yujing, Shi, ZhiHua, Zhuo, Yehong, Liu, Jing, Malakhov, Andrey, Ko, Eunhwa, Burgess, Kevin, Schaefer, Henry, Esteban, Pedro F., Tessarollo, Lino, Saragovi, H. Uri
Natura: Artigo
Lingua:Inglês
Pubblicazione: Association for Research in Vision and Ophthalmology, Inc. 2010
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3055774/
https://ncbi.nlm.nih.gov/pubmed/20574020
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.10-5431
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