A novel RNA binding protein, SBP2, is required for the translation of mammalian selenoprotein mRNAs

In eukaryotes, the decoding of the UGA codon as selenocysteine (Sec) requires a Sec insertion sequence (SECIS) element in the 3′ untranslated region of the mRNA. We purified a SECIS binding protein, SBP2, and obtained a cDNA clone that encodes this activity. SBP2 is a novel protein containing a puta...

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Veröffentlicht in:	EMBO J
Hauptverfasser:	Copeland, Paul R., Fletcher, Julia E., Carlson, Bradley A., Hatfield, Dolph L., Driscoll, Donna M.
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Nature Publishing Group 2000
Schlagworte:	Articles
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC305564/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10637234/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/19.2.306
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