A nuclear tyrosine phosphorylation circuit: c-Jun as an activator and substrate of c-Abl and JNK

The nuclear function of the c–Abl tyrosine kinase is not well understood. In order to identify nuclear substrates of Abl, we constructed a constitutively active and nuclear form of the protein. We found that active nuclear Abl efficiently phosphorylate c–Jun, a transcription factor not previously kn...

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Bibliografiske detaljer

Udgivet i:	EMBO J
Principais autores:	Barilá, Daniela, Mangano, Raffaella, Gonfloni, Stefania, Kretzschmar, Jana, Moro, Marina, Bohmann, Dirk, Superti-Furga, Giulio
Format:	Artigo
Sprog:	Inglês
Udgivet:	Nature Publishing Group 2000
Fag:	Articles
Online adgang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC305561/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10637231/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/19.2.273
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