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A nuclear tyrosine phosphorylation circuit: c-Jun as an activator and substrate of c-Abl and JNK

The nuclear function of the c–Abl tyrosine kinase is not well understood. In order to identify nuclear substrates of Abl, we constructed a constitutively active and nuclear form of the protein. We found that active nuclear Abl efficiently phosphorylate c–Jun, a transcription factor not previously kn...

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Detalhes bibliográficos
Main Authors: Barilá, Daniela, Mangano, Raffaella, Gonfloni, Stefania, Kretzschmar, Jana, Moro, Marina, Bohmann, Dirk, Superti-Furga, Giulio
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2000
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC305561/
https://ncbi.nlm.nih.gov/pubmed/10637231
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/19.2.273
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