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A nuclear tyrosine phosphorylation circuit: c-Jun as an activator and substrate of c-Abl and JNK
The nuclear function of the c–Abl tyrosine kinase is not well understood. In order to identify nuclear substrates of Abl, we constructed a constitutively active and nuclear form of the protein. We found that active nuclear Abl efficiently phosphorylate c–Jun, a transcription factor not previously kn...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Oxford University Press
2000
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC305561/ https://ncbi.nlm.nih.gov/pubmed/10637231 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/19.2.273 |
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