A nuclear tyrosine phosphorylation circuit: c-Jun as an activator and substrate of c-Abl and JNK

The nuclear function of the c–Abl tyrosine kinase is not well understood. In order to identify nuclear substrates of Abl, we constructed a constitutively active and nuclear form of the protein. We found that active nuclear Abl efficiently phosphorylate c–Jun, a transcription factor not previously kn...

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Pubblicato in:	EMBO J
Autori principali:	Barilá, Daniela, Mangano, Raffaella, Gonfloni, Stefania, Kretzschmar, Jana, Moro, Marina, Bohmann, Dirk, Superti-Furga, Giulio
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Nature Publishing Group 2000
Soggetti:	Articles
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC305561/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10637231/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/19.2.273
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