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New structural motifs on the chymotrypsin fold and their potential roles in complement factor B

Factor B and C2 are two central enzymes for complement activation. They are multidomain serine proteases and require cofactor binding for full expression of proteolytic activities. We present a 2.1 Å crystal structure of the serine protease domain of factor B. It shows a number of structural motifs...

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Bibliografiske detaljer
Main Authors: Jing, Hua, Xu, Yuanyuan, Carson, Mike, Moore, Dwight, Macon, Kevin J., Volanakis, John E., Narayana, Sthanam V.L.
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2000
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC305551/
https://ncbi.nlm.nih.gov/pubmed/10637221
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/19.2.164
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