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The Crystal Structure of C2a, the Catalytic Fragment of Classical Pathway C3- and C5-convertase of Human Complement
The multi-domain serine protease C2 provides the catalytic activity for the C3- and C5- convertases of the classical and lectin pathways of complement activation. Formation of these convertases requires the Mg(2+)-dependent binding of C2 to C4b and the subsequent cleavage of C2 by C1s or MASP2, resp...
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| Autors principals: | , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2006
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1868468/ https://ncbi.nlm.nih.gov/pubmed/17234210 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2006.12.039 |
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