The Antipsychotics Olanzapine, Risperidone, Clozapine, and Haloperidol Are D2-Selective Ex Vivo but Not In Vitro

In a recent human [(11)C]-(+)-PHNO positron emission tomography study, olanzapine, clozapine, and risperidone occupied D2 receptors in striatum (STR), but, despite their similar in vitro D2 and D3 affinities, failed to occupy D3 receptors in globus pallidus. This study had two aims: (1) to character...

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Autores principales: McCormick, Patrick N, Kapur, Shitij, Graff-Guerrero, Ariel, Raymond, Roger, Nobrega, José N, Wilson, Alan A
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2010
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Original Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3055486/
https://ncbi.nlm.nih.gov/pubmed/20410873
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/npp.2010.50
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