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XPD Helicase Structures and Activities: Insights into the Cancer and Aging Phenotypes from XPD Mutations
Mutations in XPD helicase, required for nucleotide excision repair (NER) as part of the transcription/repair complex TFIIH, cause three distinct phenotypes: cancer-prone xeroderma pigmentosum (XP) or aging disorders Cockayne syndrome (CS) and trichothiodystrophy (TTD). To clarify molecular differenc...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3055247/ https://ncbi.nlm.nih.gov/pubmed/18510924 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2008.04.030 |
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