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Topology of protein interaction network shapes protein abundances and strengths of their functional and nonspecific interactions
How do living cells achieve sufficient abundances of functional protein complexes while minimizing promiscuous nonfunctional interactions? Here we study this problem using a first-principle model of the cell whose phenotypic traits are directly determined from its genome through biophysical properti...
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| Autors principals: | , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
National Academy of Sciences
2011
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3054035/ https://ncbi.nlm.nih.gov/pubmed/21368118 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1009392108 |
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