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Topology of protein interaction network shapes protein abundances and strengths of their functional and nonspecific interactions
How do living cells achieve sufficient abundances of functional protein complexes while minimizing promiscuous nonfunctional interactions? Here we study this problem using a first-principle model of the cell whose phenotypic traits are directly determined from its genome through biophysical properti...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3054035/ https://ncbi.nlm.nih.gov/pubmed/21368118 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1009392108 |
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