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Topology of protein interaction network shapes protein abundances and strengths of their functional and nonspecific interactions

How do living cells achieve sufficient abundances of functional protein complexes while minimizing promiscuous nonfunctional interactions? Here we study this problem using a first-principle model of the cell whose phenotypic traits are directly determined from its genome through biophysical properti...

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Bibliografski detalji
Glavni autori: Heo, Muyoung, Maslov, Sergei, Shakhnovich, Eugene
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2011
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3054035/
https://ncbi.nlm.nih.gov/pubmed/21368118
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1009392108
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