Renal uptake of different radiolabelled peptides is mediated by megalin: SPECT and biodistribution studies in megalin-deficient mice

PURPOSE: Radiolabelled peptides used for peptide receptor radionuclide therapy are excreted mainly via the kidneys and are partly reabsorbed and retained in the proximal tubular cells. The resulting high renal radiation dose can cause nephrotoxicity, limiting the maximum activity dose and the effect...

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Autors principals: Vegt, Erik, Melis, Marleen, Eek, Annemarie, de Visser, Monique, Brom, Maarten, Oyen, Wim J. G., Gotthardt, Martin, de Jong, Marion, Boerman, Otto C.
Format: Artigo
Idioma:Inglês
Publicat: Springer-Verlag 2010
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3053449/
https://ncbi.nlm.nih.gov/pubmed/21170526
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00259-010-1685-9
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