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MMTV-Cre transgenes can adversely affect lactation: considerations for conditional gene deletion in mammary tissue
CRE-loxP-mediated inactivation and activation of genes in mouse mammary epithelium have been widely used to study genetic pathways in normal development and neoplastic transformation in vivo. In 1997 we generated three distinct mouse lines carrying an identical MMTV-Cre transgene (lines A, D and F)....
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| Main Authors: | , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2011
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3053441/ https://ncbi.nlm.nih.gov/pubmed/21255551 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ab.2011.01.020 |
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