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M1 Muscarinic Receptors Boost Synaptic Potentials and Calcium Influx in Dendritic Spines by Inhibiting Postsynaptic SK channels

Acetylcholine release and activation of muscarinic cholinergic receptors (mAChRs) enhance synaptic plasticity in vitro and cognition and memory in vivo. Within the hippocampus, mAChRs enhance NMDA-type glutamate receptor-dependent forms of long-term potentiation. Here, we use calcium (Ca) imaging co...

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Bibliographic Details
Main Authors: Giessel, Andrew J., Sabatini, Bernardo L.
Format: Artigo
Language:Inglês
Published: 2010
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3052967/
https://ncbi.nlm.nih.gov/pubmed/21145006
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2010.09.004
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