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Trimethylation of histone H3 lysine 4 impairs methylation of histone H3 lysine 9: Regulation of lysine methyltransferases by physical interaction with their substrates

Chromatin is broadly compartmentalized in two defined states: euchromatin and heterochromatin. Generally, euchromatin is trimethylated on histone H3 lysine 4 (H3K4(me3)) while heterochromatin contains the H3K9(me3) mark. The H3K9(me3) modification is added by lysine methyltransferases (KMTs) such as...

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Hlavní autoři: Binda, Olivier, LeRoy, Gary, Bua, Dennis J, Garcia, Benjamin A, Gozani, Or, Richard, Stéphane
Médium: Artigo
Jazyk:Inglês
Vydáno: Landes Bioscience 2010
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3052887/
https://ncbi.nlm.nih.gov/pubmed/21124070
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/epi.5.8.13278
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