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Catechol O-Methyltransferase Pharmacogenomics: Human Liver Genotype-Phenotype Correlation and Proximal Promoter Studies
OBJECTIVES: Catechol O-methyltransferase (COMT) is expressed as both soluble (S) and membrane-bound (MB) isoforms, with S-COMT predominantly expressed in liver. A common nonsynonymous SNP, 472G>A (108/158Val>Met, S/MB), has been associated with variation in levels of COMT enzyme activity and t...
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| Autores principales: | , , , , , , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2009
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3052748/ https://ncbi.nlm.nih.gov/pubmed/19641441 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/FPC.0b013e32832c15c6 |
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