Melatonin, a novel Sirt1 inhibitor, imparts anti-proliferative effects against prostate cancer in vitro in culture and in vivo in TRAMP model

We recently demonstrated that Sirt1, a NAD(+) dependent histone deacetylase, was overexpressed in prostate cancer (PCa) and its inhibition resulted in a significant anti-proliferative response in human PCa cells. Studies have suggested a link between Sirt1 and circadian rhythms, the disruption of wh...

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Détails bibliographiques
Auteurs principaux: Jung-Hynes, Brittney, Schmit, Travis L., Reagan-Shaw, Shannon R., Siddiqui, Imtiaz A., Mukhtar, Hasan, Ahmad, Nihal
Format: Artigo
Langue:Inglês
Publié: 2010
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3052633/
https://ncbi.nlm.nih.gov/pubmed/21062352
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1600-079X.2010.00823.x
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