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Melatonin, a novel Sirt1 inhibitor, imparts anti-proliferative effects against prostate cancer in vitro in culture and in vivo in TRAMP model
We recently demonstrated that Sirt1, a NAD(+) dependent histone deacetylase, was overexpressed in prostate cancer (PCa) and its inhibition resulted in a significant anti-proliferative response in human PCa cells. Studies have suggested a link between Sirt1 and circadian rhythms, the disruption of wh...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3052633/ https://ncbi.nlm.nih.gov/pubmed/21062352 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1600-079X.2010.00823.x |
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