Removal of transposon target sites from the Autographa californica multiple nucleopolyhedrovirus fp25k gene delays, but does not prevent, accumulation of the few polyhedra phenotype

Low-cost, large-scale production of the baculovirus Autographa californica multiple nucleopolyhedrovirus (AcMNPV) using continuous insect cell culture is seriously hindered by the accumulation of AcMNPV mutants. Specifically, few-polyhedra (FP) mutants, with a reduced yield of occluded virus (polyhe...

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Autores principales: Giri, Lopamudra, Li, Huarang, Sandgren, David, Feiss, Michael G., Roller, Richard, Bonning, Bryony C., Murhammer, David W.
Formato: Artigo
Lenguaje:Inglês
Publicado: Society for General Microbiology 2010
Materias:
Animal
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3052567/
https://ncbi.nlm.nih.gov/pubmed/20810745
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1099/vir.0.024430-0
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