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Integration of IGF, FGF, and anti-BMP signals via Smad1 phosphorylation in neural induction

How do very diverse signaling pathways induce neural differentiation in Xenopus? Anti-BMP (Chordin), FGF8, and IGF2 signals are integrated in the embryo via the regulation of Smad1 phosphorylation. Neural induction results from the combined inhibition of BMP receptor serine/threonine kinases and act...

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Autors principals: Pera, Edgar M., Ikeda, Atsushi, Eivers, Edward, De Robertis, Eddy M.
Format: Artigo
Idioma:Inglês
Publicat: Cold Spring Harbor Laboratory Press 2003
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC305254/
https://ncbi.nlm.nih.gov/pubmed/14701872
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1153603
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