Modification of DNA ends can decrease end joining relative to homologous recombination in mammalian cells.
In animal cells, exogenous DNA recombines into random chromosomal sites much more frequently than it recombines into homologous sites. Free DNA ends are "recombinogenic" in both processes. To test the effects of specific ends on analogous extrachromosomal processes, we constructed a linear genome of...
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| Published in: | Proc Natl Acad Sci U S A |
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| Main Authors: | , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
National Academy of Sciences
1987
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC305226/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3037530/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.84.14.4959 |
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