Multiple point mutations in a shuttle vector propagated in human cells: evidence for an error-prone DNA polymerase activity.

Mutagenesis was studied at the DNA-sequence level in human fibroblast and lymphoid cells by use of a shuttle vector plasmid, pZ189, containing a suppressor tRNA marker gene. In a series of experiments, 62 plasmids were recovered that had two to six base substitutions in the 160-base-pair marker gene...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Seidman, M M, Bredberg, A, Seetharam, S, Kraemer, K H
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 1987
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC305223/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3474635/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.84.14.4944
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