Immunization with different PfAMA1 alleles in sequence induces clonal imprint humoral responses that are similar to responses induced by the same alleles as a vaccine cocktail in rabbits

BACKGROUND: Antibodies to key Plasmodium falciparum surface antigens have been shown to be important effectors that mediate clinical immunity to malaria. The cross-strain fraction of anti-malarial antibodies may however be required to achieve strain-transcending immunity. Such antibody responses aga...

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Main Authors: Kusi, Kwadwo A, Faber, Bart W, van der Eijk, Marjolein, Thomas, Alan W, Kocken, Clemens HM, Remarque, Edmond J
Format: Artigo
Language:Inglês
Published: BioMed Central 2011
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Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3050776/
https://ncbi.nlm.nih.gov/pubmed/21320299
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1475-2875-10-40
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