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The role of hypoxia-inducible factors in tumorigenesis
Hypoxia-inducible factors (HIFs) are essential mediators of the cellular oxygen-signaling pathway. They are heterodimeric transcription factors consisting of an oxygen-sensitive alpha subunit (HIF-α) and a constitutive beta subunit (HIF-β) that facilitate both oxygen delivery and adaptation to oxyge...
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| Main Authors: | , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2008
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3050610/ https://ncbi.nlm.nih.gov/pubmed/18259193 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2008.21 |
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