Genetic predisposition directs breast cancer phenotype by dictating progenitor cell fate

Women with inherited mutations in the BRCA1 gene have increased risk of developing breast cancer, but also exhibit a predisposition for the development of aggressive basal-like breast tumors. We report here that breast epithelial cells derived from patients harboring deleterious mutations in BRCA1 (...

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Detalhes bibliográficos
Main Authors: Proia, Theresa A., Keller, Patricia J., Gupta, Piyush B., Klebba, Ina, Jones, Ainsley D., Sedic, Maja, Gilmore, Hannah, Tung, Nadine, Naber, Stephen P., Schnitt, Stuart, Lander, Eric S., Kuperwasser, Charlotte
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3050563/
https://ncbi.nlm.nih.gov/pubmed/21295272
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2010.12.007
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