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BRCA1-hapoinsufficiency: Unraveling the molecular and cellular basis for tissue-specific cancer

Over the past 20 years tremendous progress has been made in understanding the function of BRCA1 gene products. Yet one question still remains: why is mutation of BRCA1 typically associated with preferential development of breast and ovarian cancers and not tumors in other tissues? Here we discuss re...

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Detalhes bibliográficos
Publicado no:Cell Cycle
Main Authors: Sedic, Maja, Kuperwasser, Charlotte
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4845926/
https://ncbi.nlm.nih.gov/pubmed/26822887
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384101.2016.1141841
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