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Threshold levels of Flt3-ligand are required for the generation and survival of lymphoid progenitors and B cell precursors
The generation of B cell precursors (BCP) from lymphohematopoietic progenitors (LHP) in bone marrow is dependent on signals provided by the receptor tyrosine kinase Flt3 and its ligand, Flt3-ligand (FL). Mice deficient in FL exhibit striking reductions in LHP and BCP. Currently the mechanism by whic...
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| Main Authors: | , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2011
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3050551/ https://ncbi.nlm.nih.gov/pubmed/21268003 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/eji.201040710 |
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