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Threshold levels of Flt3-ligand are required for the generation and survival of lymphoid progenitors and B cell precursors

The generation of B cell precursors (BCP) from lymphohematopoietic progenitors (LHP) in bone marrow is dependent on signals provided by the receptor tyrosine kinase Flt3 and its ligand, Flt3-ligand (FL). Mice deficient in FL exhibit striking reductions in LHP and BCP. Currently the mechanism by whic...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
मुख्य लेखकों: Dolence, Joseph J., Gwin, Kimberly, Frank, Elena, Medina, Kay L.
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: 2011
विषय:
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC3050551/
https://ncbi.nlm.nih.gov/pubmed/21268003
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/eji.201040710
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