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Molecular Basis for the Inability of an Oxygen Atom Donor Ligand to Replace the Natural Sulfur Donor Heme Axial Ligand in Cytochrome P450 Catalysis. Spectroscopic Characterization of the Cys436Ser CYP2B4 Mutant
All cytochrome P450s (CYPs) contain a cysteinate heme iron proximal ligand that plays a crucial role in their mechanism of action. Conversion of the proximal Cys436 to Ser in NH(2)-truncated microsomal CYP2B4 (ΔCYP2B4) transforms the enzyme into a two-electron NADPH oxidase producing H(2)O(2) withou...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3050543/ https://ncbi.nlm.nih.gov/pubmed/21147058 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.abb.2010.12.010 |
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